Published in Nature Communications, 2019
While many pleiotropic genetic loci have been identified, how they contribute to phenotypes across traits and diseases is unclear. Here, the authors propose decomposition of genetic associations (DeGAs), which uses singular value decomposition, to characterize the underlying latent structure of genetic associations of 2,138 phenotypes.
Citation: Y. Tanigawa*, J. Li*, J. M. Justesen, H. Horn, M. Aguirre, C. DeBoever, C. Chang, B. Narasimhan, K. Lage, T. Hastie, C. Y. Park, G. Bejerano, E. Ingelsson, M. A. Rivas, Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology. Nat Commun. 10, 1–14 (2019). https://doi.org/10.1038/s41467-019-11953-9