Publications

You can also find my articles and recent preprints on my Google Scholar profile.

Preprints

[Preprint] Cardiac imaging of aortic valve area from 26,142 UK Biobank participants reveal novel genetic associations and shared genetic comorbidity with multiple disease phenotypes

Preprint posted on medRxiv, 2020

Citation: A. Cordova-Palomera, C. Tcheandjieu, J. Fries, P. Varma, V. Chen, M. Fiterau, K. Xiao, H. Tejeda, B. Keavney, H. Cordell, Y. Tanigawa, G. Venkataraman, M. Rivas, C. Re, E. Ashley, J. R. Priest, Cardiac imaging of aortic valve area from 26,142 UK Biobank participants reveal novel genetic associations and shared genetic comorbidity with multiple disease phenotypes. medRxiv, 2020.04.09.20060012 (2020). https://doi.org/10.1101/2020.04.09.20060012

[Preprint] Medical relevance of common protein-altering variants in GPCR genes across 337,205 individuals in the UK Biobank study

Preprint posted on bioRxiv, 2019

Citation: C. DeBoever, A. J. Venkatakrishnan, J. M. Paggi, F. M. Heydenreich, S.-A. Laurin, M. Masureel, Y. Tanigawa, G. Venkataraman, M. Bouvier, R. Dror, M. A. Rivas, Medical relevance of common protein-altering variants in GPCR genes across 337,205 individuals in the UK Biobank study. bioRxiv, 2019.12.13.876250 (2019). https://doi.org/10.1101/2019.12.13.876250

[Preprint] Genetics of 38 blood and urine biomarkers in the UK Biobank

Preprint posted on bioRxiv, 2019

Citation: N. Sinnott-Armstrong*, Y. Tanigawa*, D. Amar, N. J. Mars, M. Aguirre, G. R. Venkataraman, M. Wainberg, H. M. Ollila, J. P. Pirruccello, J. Qian, A. Shcherbina, FinnGen, F. Rodriguez, T. L. Assimes, V. Agarwala, R. Tibshirani, T. Hastie, S. Ripatti, J. K. Pritchard, M. J. Daly, M. A. Rivas, Genetics of 38 blood and urine biomarkers in the UK Biobank. bioRxiv, 660506 (2019). https://doi.org/10.1101/660506

Peer-reviewed publications

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

Published in PLOS Genetics, 2020

Citation: Y. Tanigawa, M. Wainberg, J. Karjalainen, T. Kiiskinen, G. Venkataraman, S. Lemmelä, J. A. Turunen, R. R. Graham, A. S. Havulinna, M. Perola, A. Palotie, FinnGen, M. J. Daly, M. A. Rivas, Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma. PLOS Genetics. 16, e1008682 (2020). https://doi.org/10.1371/journal.pgen.1008682

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

Published in Nature Communications, 2019

While many pleiotropic genetic loci have been identified, how they contribute to phenotypes across traits and diseases is unclear. Here, the authors propose decomposition of genetic associations (DeGAs), which uses singular value decomposition, to characterize the underlying latent structure of genetic associations of 2,138 phenotypes.

Citation: Y. Tanigawa*, J. Li*, J. M. Justesen, H. Horn, M. Aguirre, C. DeBoever, C. Chang, B. Narasimhan, K. Lage, T. Hastie, C. Y. Park, G. Bejerano, E. Ingelsson, M. A. Rivas, Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology. Nat Commun. 10, 1–14 (2019). https://doi.org/10.1038/s41467-019-11953-9

SNPs2ChIP: Latent Factors of ChIP-seq to infer functions of non-coding SNPs

Published in Pacific Symposium on Biocomputing, 2018

We propose SNPs2ChIP, a method to infer biological functions of non-coding variants through unsupervised statistical learning methods applied to publicly-available epigenetic datasets.

Citation: S. Anand, L. Kalesinskas, C. Smail, Y. Tanigawa, SNPs2ChIP: Latent Factors of ChIP-seq to infer functions of non-coding SNPs. Pac Symp Biocomput. 2019, 24: 184-195 (WORLD SCIENTIFIC, 2018). https://doi.org/10.1142/9789813279827_0017

Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study

Published in Nature Communications, 2018

Using the UK Biobank population cohort, we investigated the genetic effects of Protein-truncating variants (PTVs) and the clinical impacts.

Citation: C. DeBoever, Y. Tanigawa, M. E. Lindholm, G. McInnes, A. Lavertu, E. Ingelsson, C. Chang, E. A. Ashley, C. D. Bustamante, M. J. Daly, M. A. Rivas, Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study. Nat Commun. 9, 1612 (2018). https://doi.org/10.1038/s41467-018-03910-9

Collaborative environmental DNA sampling from petal surfaces of flowering cherry Cerasus × yedoensis ‘Somei-yoshino’ across the Japanese archipelago

Published in Journal of Plant Research, 2018

Citation: T. Ohta, T. Kawashima, N. O. Shinozaki, A. Dobashi, S. Hiraoka, T. Hoshino, K. Kanno, T. Kataoka, S. Kawashima, M. Matsui, W. Nemoto, S. Nishijima, N. Suganuma, H. Suzuki, Y. Taguchi, Y. Takenaka, Y. Tanigawa, M. Tsuneyoshi, K. Yoshitake, Y. Sato, R. Yamashita, K. Arakawa, W. Iwasaki, Collaborative environmental DNA sampling from petal surfaces of flowering cherry Cerasus × yedoensis ‘Somei-yoshino’ across the Japanese archipelago. J Plant Res. 131, 709–717 (2018). https://doi.org/10.1007/s10265-018-1017-x