Yosuke works at the intersection of statistical genetics and computational biology. Specifically, he develops computational and statistical methods to dissect disease heterogeneity and apply them in systematic analyses of large-scale phenotypic, genetic, epigenomic, functional genomic, and single-cell genomic datasets.
Please check CV, Publications, and/or Google Scholar profile for list of publications and pre-prints. Please also check Resources page for datasets, analysis and visualization scripts, and web applications from our research activities.
- Application of statistical genetics for human disease genetic studies. I am specifically interested in the analysis of population biobanks.
- Statistical and computational method development for large-scale datasets in the context of human genomic studies.
- Functional analysis of non-coding regions in the human genome. I am specifically interested in the analysis of transcription factors.
- 2022/11/16: Yosuke will participate panel discussion at the Genetics and Genomics Digital Forum hosted by the American Society of Human Genetics.
- 2022/11/12-16: Yosuke will present at Neuroscience 2022 (Society for Neuroscience Annual meeting) at San Diego, CA, USA.
- 2022/11/7-11: Yosuke will present at 14th ISCB Conference on Regulatory & Systems Genomics with DREAM Challenges 2022 at Las Vegas, NV, USA.
- 2022/10/25-29: Yosuke will present at the American Society of Human Genetics Annual meeting 2022 at Los Angeles, CA, USA.
- 2022/10/27 10:45 am - 11:00 am at Conv Ctr/Room 515/West
- Title: “Single-cell Transcriptional Hallmarks and Individual Subtyping for Alzheimer’s Disease across 427 subjects”
- My talk is a part of “The methylome and transcriptome of complex traits” platform session.
- 2022/10/4: New Publication “Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells”. Congrats, Jackie, Maria, Pasquale, and the team!
- 2022/8/30: New Publication “WhichTF is dominant in your open chromatin data?”. We develop an ontology-guided approach to ranking tissue-/cell-type-specific transcription factors (TFs) from chromatin accessibility data. This paper describes the last chapter of my Ph.D. thesis and I am so happy to see this out.
- 2022/8/30: New Publication “Deconvoluting complex correlates of COVID19 severity with a multi-omic pandemic tracking strategy”. Congrats, Vicki, Alex and the team!
- 2022/7/19: New Publication. “Large-scale multivariate sparse regression with applications to UK Biobank.” Congrats, Junyang and the team!
- 2022/7/11: Yosuke presented “Single-cell transcriptional hallmarks and patient subtyping for Alzheimer’s disease” at ROS/MAP meeting 2022 at Rush University Medical Center, Chicago, IL.
- 2022/6/7: Yosuke presented a poster titled, “Single-cell transcriptional hallmarks of Alzheimer’s disease across 427 individuals” at the Broad Institute Poster Day 2022.
- 2022/6/2: New Publication. “Integration of rare expression outlier-associated variants improves polygenic risk prediction.” Congrats, Craig and the team!
- 2022/5/10-14: Yosuke presented a poster titled, “Single-cell transcriptional hallmarks of Alzheimer’s disease across 427 individuals” at Biology of the Genomes conference at Cold Spring Harbor Laboratory.
- 2022/3/24: New Publication “Significant sparse polygenic risk scores across 813 traits in UK Biobank”. We performed a systematic assessment of the predictive performance of polygenic risk score (PRS) models across >1,500 traits in UK Biobank and report 813 PRS models with significant predictive performance.
- 2022/03/02: Yosuke presented polygenic score analyses at University of Osaka, Japan.
- 2022/01/28: Yosuke presented at Journal Club meeting at Debora Marks’s lab.
- 2022/01/27: Updated manuscript. We posted updated manuscript, titled Significant Sparse Polygenic Risk Scores across 813 traits in UK Biobank on medRxiv.
- 2022.01.01: Happy New Year!
- cf. News Archive
I write blog posts mostly on computing tips, including:
- GWAS and genetic analyses with PLINK2 and pgenlibr
- Notes on Apache Columnar format
- Working with very small values in R
- Commonly used commands in high performance cluster computing with Slurm workload manager
Email is the best contact to reach out to me. If you do not get a reply within two days, please do not hesitate to follow-up. Thank you very much for your interest in our work.
yosuke <dot> tanigawa [at] alumni <dot> stanford <dot> edu
- Social media accounts can be found on the left (for PC) or “Follow” button on the top (for smartphone).