Bayesian model comparison for rare-variant association studies of multiple phenotypes
Published in Am J Hum Genet, 2021
When applied to cardiometabolic biomarker traits in UK Biobank, MRP identified gene-biomarker associations that were not identified in single-variant GWAS analysis.
Reference: G. R. Venkataraman, C. DeBoever, Y. Tanigawa, M. Aguirre, A. G. Ioannidis, H. Mostafavi, C. C. A. Spencer, T. Poterba, C. D. Bustamante, M. J. Daly, M. Pirinen, M. A. Rivas, Bayesian model comparison for rare-variant association studies. Am J Hum Genet. 108(12), 2354-2367 (2021). https://doi.org/10.1016/j.ajhg.2021.11.005 (full text)