[Preprint] Sex-specific genetic effects across biomarkers

Preprint posted on bioRxiv, 2019

This preprint is now published in European Journal of Human Genetics!

In this study led by Emily Flynn, we discovered a surprising sex-specificity in the genetics of testosterone. Yosuke performed polygenic risk score (PRS) analysis and demonstrated that PRS models trained for each sex show improvements in predictive accuracy.

SEMM PRS figure

Citation: E. Flynn, Y. Tanigawa, F. Rodriguez, R. B. Altman, N. Sinnott-Armstrong, M. A. Rivas, Sex-specific genetic effects across biomarkers. bioRxiv, 837021 (2019). https://doi.org/10.1101/837021