Sex-specific genetic effects across biomarkers

Published in European Journal of Human Genetics, 2020

In this study led by Emily Flynn, we discovered a surprising sex-specificity in the genetics of testosterone. Yosuke performed the polygenic risk score (PRS) analysis and demonstrated that PRS models trained for each sex improve predictive accuracy.

SEMM PRS figure

We made the sex-specific polygenic risk score models publicly available.

Reference: E. Flynn, Y. Tanigawa, F. Rodriguez, R. B. Altman, N. Sinnott-Armstrong, M. A. Rivas, Sex-specific genetic effects across biomarkers. Eur J Hum Genet, 29(1), 154-163 (2021). (full text)