Statin is a commonly used drug for high cholesterol. Physicians adjust the type and dose of statin based on the observed response to the treatment. To investigate the role of genetics, we performed genome-wide association scan to identify genetic variants associated with statin selection. When we investigated the identified variants in LPA and APOE, we found that the carriers of those variants are more likely to be on a higher dose of statin.
Reference: A. Lavertu*, G. M. McInnes*, Y. Tanigawa, R. B. Altman, M. A. Rivas, LPA and APOE are associated with statin selection in the UK Biobank. bioRxiv, 2020.08.28.272765 (2020). https://doi.org/10.1101/2020.08.28.272765