Fast Numerical Optimization for Genome Sequencing Data in Population Biobanks

Published in Bioinformatics, 2021

In this paper led by Ruilin Li, we describe memory-efficient implementation of snpnet (sparse-snpnet and snpnet-v2).

This paper extends our previous works on the polygenic risk modeling with BAtch Iterative Screening Lasso (BASIL).

snpnet v2 fig 2

Citation: R. Li, C. Chang, Y. Tanigawa, B. Narasimhan, T. Hastie, R. Tibshirani, M. A. Rivas, Fast Numerical Optimization for Genome Sequencing Data in Population Biobanks. Bioinformatics (2021). https://doi.org/10.1093/bioinformatics/btab452