[Preprint] Genetics of cardiometabolic disease progression.

In this study led by Johanne M. Justesen in the Rivas lab, we investigate the genetic basis of cardiometabolic disease progression, ascertained by the time from the initial diagnosis to time to complication/comorbidity diagnosed or procedure in the UK Biobank.

Applying the Cox regression model in a time-to-event setting using snpnet-Cox, the study shows that the genetic basis of disease progression provides opportunities to stratify individuals using polygenic hazard scores (PHS), offering substantial implications for guiding treatment decisions.